Layer-by-layer assembly of polyarginine and poly(ethylene glycol)-block-poly (l-aspartic acid) polymers to enhance the systemic performance of albumin-bound paclitaxel nanoparticle

• In: Poster presentation
• At: Seoul (South Korea) (2017)
• Type: Poster
• Poster code: POS-FDP-038
• By: YONG, Chul Soon (Yeungnam University, Gyeongsan-Si, Korea, Republic Of)
• Co-author(s): Woo Hyun Shin: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
  Hima Bindu Ruttala: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
  Jae-Myung Lee: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
  Dong Shik Kim: Hanyang University, Ansan-si, Korea, Republic Of
  Jee-Heon Jeong: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
  Han-Gon Choi: Hanyang University, Ansan-si, Korea, Republic Of
  Chul Soon Yong: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
  Jong Oh Kim: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
  
• Abstract:

  Background

  Protein bound paclitaxel is limited by poor biodistribution and acute toxicity. We have tried to develop a layer by layer approach on the surface of the albumin nanoparticle to enhance its systemic performance.

  Purpose

  We aimed to apply the principles of a layer-by-layer(LbL) technique to improve the poor colloidal stability and..

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