Comparative bioavailability of a drug in a peg based solution using an iprecio® pump infusion and subcutaneous bolus

• In: Poster presentation
• At: Seoul (South Korea) (2017)
• Type: Poster
• Poster code: POS-PAA-020
• By: TEIXEIRA, João (Bial - Portela & Cª, S.A., R&D Department, Trofa, Portugal)
• Co-author(s): João Teixeira: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal
  Nuno Pires: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal
  Bruno Igreja: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal
  Ana Loureiro: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal
  Teófilo Vasconcelos: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal
  Ricardo Lima: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal
  Patrício Soares-da-Silva: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal;MedInUP, Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal
  
• Abstract:

  Background

  iPrecio^® microinfusion pumps are programmable, implantable and refillable devices for small animal experimentation, showing advantages over the subcutaneous (SC) bolus administration.

  Purpose

  The aim of this study was to compare the plasma and brain time course pharmacokinetic (PK) profile of a drug delivered from iPrecio pumps versus a SC

  ..

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