Preparation of rivaroxaban nanocrystals with wet ball milling

• In: Poster presentation
• At: Seoul (South Korea) (2017)
• Type: Poster
• Poster code: POS-FDP-006
• By: DEMIR, Huriye (Hacettepe University Faculty of Pharmacy, Department of Pharmaceutical Technology, ANKARA, Turkey)
• Co-author(s): Huriye Demir : Department of Pharmaceutical Technology, Hacettepe University Faculty of Pharmacy, ANKARA, Turkey
  Selma Sahin: Department of Pharmaceutical Technology, Hacettepe University Faculty of Pharmacy, ANKARA, Turkey
  Levent Oner: Department of Pharmaceutical Technology, Hacettepe University Faculty of Pharmacy, ANKARA, Turkey
  
• Abstract:

  Background

  The reduced particle size and increased surface area of nanocrystals can lead to increase in the dissolution rate of poorly soluble compounds such as rivaroxaban (RXB).

  Purpose

  The aim of this study was to prepare RXB nanocrystals, and then determine its dissolution rate from these formulations. 

  Methods

  Rivaroxaban as the model compound,

  ..

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