Development of a pbpk model for di-2-ethylhexyl phthalate and its active metabolites, mono-2-ethylhexyl phthalate, mono-2-ethyl-5-hydroxyhexyl phthalate and mono-2-ethyl-5-oxohexyl phthalate, in rats

• In: Poster presentation
• At: Seoul (South Korea) (2017)
• Type: Poster
• Poster code: POS-PAA-015
• By: PARK, Sungwook (School of Pharmacy, Sungkyunkwan University, 수원시 장안구, Korea, Republic Of)
• Co-author(s): Sungwook Park: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
  Sang Min Kim: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
  Tae Hwan Kim: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
  Junwoo Park: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
  Beom Soo Shin: College of Pharmacy, Catholic University of Daegu, Gyeongsan, Korea, Republic Of
  Sun Dong Yoo: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
  
• Abstract:

  Background

  Di-2-ethylhexyl phthalate (DEHP) is a plasticizer used in the manufacture of a variety of common products made of PVC. The most common exposure to DEHP occurs via the oral route. Following ingestion, it is rapidly metabolized to mono-2-ethylhexyl phthalate (MEHP). MEHP is then metabolized to mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP)..

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