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Solubility and formulate-ability: key molecular determinants of developability of ligands to contemporary targets

  • In: SYMPOSIUM: CHALLENGES FOR THE DEVELOPMENT OF DRUGS WITH LOW AQUEOUS SOLUBILITY AND/OR LOW PERMEABILITY on Monday, 14 April 2014, 10:30-12:00
  • At: PSWC, Melbourne (Australia) (2014)
  • Type: Presentation
  • By: BERGSTROM, Christel A.S. (Uppsala University, Pharmacy, Uppsala, Sweden)
  • Abstract:

    Large research efforts are currently directed towards solubility enhancing strategies due to the poor solubility profile of new chemical entities (NCEs). The molecular reasons for poor solubility are related to the strength of intermolecular bonds in the solid material of the drug and the strength of the bonds formed between the drug and the water ..

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Last update 28 September 2023

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