Synthesis and anticancer activity of 2-substituted aminomethyl-5-methylenecyclopentanones as apoptosis inducers through down-regulating c-flip
- In: SUBMITTED ORALS on Monday, 14 April 2014, 14:00-15:30
- At: PSWC, Melbourne (Australia) (2014)
- Type: Presentation
- By: ZHAO, Linxiang (Shenyang Pharmaceutical University, Shenyang, China)
- Co-author(s): Liu, Dan (Shenyang Pharmaceutical University, Shenyang, China)
Jing, Yongkui (Mount Sinai School of Medicine, NewYork, United States of America) - Abstract:
Mitochindrial-mediated apoptosis pathway is a main mechanism of action of chemotherapy-induced cell death in cancer. Since resistance and relpase usually occur in cancers originally responded to chemotherapy, to activate the altherantive death-receptor-mediated pathway should significantly improve the therapeutic outcome of cancer treatment...
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Last update 28 September 2023