Stability of oxytocin: aqueous vs. solid state
- In: Posters D - Formulation Design and Pharmaceutical Technology
- At: PSWC, Melbourne (Australia) (2014)
- Type: Poster
- Poster code: PD-079
- By: NASSTA, Gemma (Monash University, Drug Delivery, Disposition and Dynamics, Melbourne, Australia)
- Co-author(s): Michelle, Mcintosh (Monash University, Melbourne, Australia)
Morton, David (Monash University, Melbourne, Australia)
Prankerd, Richard (Monash University, Melbourne, Australia) - Abstract:
Introduction: The degradation mechanisms of a disulphide bond-containing peptide, oxytocin (OT), are currently open to speculation. Peptides and proteins containing disulphide bonds have been shown to undergo degradation via two distinct mechanisms: β-elimination, catalysed by hydroxide ions, followed by disulphide exchange. As the disulphide..
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Last update 28 September 2023