High concentration drug products in pre-filled syringes: clogging issue

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-C-011-Monday
• By: DE BARDI, Monica (F. Hoffmann-La Roche Ltd, Late Stage Pharmaceutical and Process Development, Basel, Switzerland)
• Co-author(s): Monica De Bardi: Late Stage Pharmaceutical and Process Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland;Department of Physics, University of Basel, Basel, Switzerland
  Mathieu Rigollet: Device Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland
  Frank Bamberg: Device Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland
  Robert Müller: Late Stage Pharmaceutical and Process Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland
  Thomas A. Jung: Department of Physics, University of Basel, Basel, Switzerland
  Kewei Yang: Late Stage Pharmaceutical and Process Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland
  
• Abstract:

  Backgrounds

  In pre-filled syringes (PFS) filled with high concentration drug products a progressive gelation of the liquid in the needle might occur, leading to a blockage and a consequent incorrect administration of the drug. Under certain storage conditions water vapor might diffuse to the environment through the rubber of the needle shield..

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