In vitro investigation of Russian original benzodiazepine phenazepam pharacokinetics: cell culture with substrate-inhibitor panel in microbioreactor

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-E-015-Monday
• By: IVASHCHENKO, Dmitriy (Russian Medical Academy of Continuous Professional Education, Moscow, Russia, Moscow, Russian Federation)
• Co-author(s): Dmitriy Ivashchenko: Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
  Andrey Poloznikov: SRC Bioclinicum, Moscow, Russian Federation
  Sergey Nikulin: SRC Bioclinicum, Moscow, Russian Federation
  Lyudmila Savchenko: Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
  Eugeniy Bryun: Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
  Dmitriy Sychev: Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
  
• Abstract:

  Backgrounds

  Phenazepam (brom-dihydrochlorphenyl-benzodiazepine) is a very common benzodiazepine drug in post-soviet countries. Although it was introduced in 1970s, there was no significant information about liver metabolism of phenazepam. It was hypothesized, that CYP3A-family enzymes could oxidize it, but the assumption required confirmation.

  Aims

  To
  ..

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