Downregulation of CD200 immunoregulatory marker in CLL patients’ lymphocytes using polyethylenimine-loaded shRNA

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-E-023-Tuesday
• By: SABOURI, Pooria (Shiraz, Iran, Islamic Republic Of)
• Co-author(s): Pooria Sabouri: Department of Pharmaceutical Biotechnology, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic Of
  Bahman Khalvati: Department of Pharmaceutical Biotechnology, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic
  
• Abstract:

  Backgrounds

  CD200 plays a key role in immune system regulation. It has been shown to be upregulated on the surface of different tumors including chronic lymphocytic leukemia (CLL) and is associated with metastasis.

  Aims

  In this investigation, we conjugated polyethylenimine (PEI) with succinic anhydride at four substitution degrees. We evaluated the
  ..

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