A comprehensive pharmacokinetic modeling of aceclofenac metabolism to major metabolites in healthy volunteers

• In: Poster presentation
• At: Seoul (South Korea) (2017)
• Type: Poster
• Poster code: POS-PAA-010
• By: KIM, Eunyoung (Chungang University, Department of Health, Social and Clinical Pharmacy, College of Pharmacy, Seoul, Korea, Republic Of)
• Co-author(s): Eunyoung Kim: Department of Health, Social and Clinical Pharmacy, College of Pharmacy, Chungang University, Seoul, Korea, Republic Of
  Wonku Kang: College of Pharmacy, Chungang University, Seoul, Korea, Republic Of
  
• Abstract:

  Background

  Aceclofenac has been used widely as a potent analgesic and anti-inflammatory drug. Aceclofenac is converted to its major  metabolites via CYP2C9-mediated hydroxylation and hydrolysis.

  Purpose

  The main purpose of this study was to develop a pharmacokinetic model reflecting the metabolic pathway of aceclofenac using a compartmental modeling..

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