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The effects of gastric ph on the pharmacokinetics of atazanavir in healthy volunteers
- In: Posters G - Pharmacokinetics (PK), Pharmacodynamics (PD) and Systems Pharmacology
- At: PSWC, Melbourne (Australia) (2014)
- Type: Poster
- Poster code: PG-012
- By: WU, Hsin-Fang (UCSF, San francisco, United States of America)
- Co-author(s): Faber, Kathleen (University of California-San Francisco, San francisco, United States of America)
Benet, Leslie Z. (University of California-San Francisco, San francisco, United States of America) - Abstract:
I.Significant pharmacokinetic interactions exist between gastric acid reducing agents and certain protease inhibitors, including atazanavir (ATV), which rely on acidic gastric pH for optimal absorption. In the presence of omeprazole, ATV exposure was reduced by 76% in healthy volunteers, raising the concern that concomitant administration of ATV..
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Last update 28 September 2023