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Inhibition of basolateral efflux transporter causes drug induced bile acids-dependent hepatotoxicity
- In: Posters G - Pharmacokinetics (PK), Pharmacodynamics (PD) and Systems Pharmacology
- At: PSWC, Melbourne (Australia) (2014)
- Type: Poster
- Poster code: PG-045
- By: SUSUKIDA, Takeshi (Graduate School of Pharmaceutical Sciences, Chiba University, Laboratory of Biopharmaceutics, Chiba, Japan)
- Abstract:
[Background and Aims] Bile salt export pump (BSEP) is localized on canalicular membrane of hepatocytes and plays a role of bile acids (BAs) efflux into bile. Dysfunction of BSEP may lead to cholestatic liver injury due to BAs accumulation in hepatocytes. We have constructed a method using sandwich cultured hepatocytes (SCHs) to evaluate..
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Last update 28 September 2023