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Unravelling the cause of the type 2 diabetes epidemic in South Asians: role for the endocannabinoid system?
- In: Short Communications A3 on Tuesday, 23 May 2017, 11:15-12:30
- At: Stockholm (Sweden) (2017)
- Type: Presentation
- By: KANTAE, Vasudev (University of Leiden, LACDR, Leiden, Netherlands)
- Co-author(s): Vasudev Kantae: LACDR, University of Leiden, Leiden, Netherlands
Kimberly J. Nahon: Endocrinology, LUMC, Leiden, Netherlands;Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, Netherlands
Maaike Straat: Endocrinology, LUMC, Leiden, Netherlands;Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, Netherlands
Leontine E.H. Bakker: Endocrinology, LUMC, Leiden, Netherlands;Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, Netherlands
Amy C Harms: LACDR, University of Leiden, Leiden, Netherlands
Mario Van Der Stelt: LIC, University of Leiden, Leiden, Netherlands
Mariëtte R. Boon: Endocrinology, LUMC, Leiden, Netherlands;Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, Netherlands
Ingrid M. Jazet: Endocrinology, LUMC, Leiden, Netherlands;Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, Netherlands
Thomas Hankemeier: LACDR, University of Leiden, Leiden, Netherlands
Patrick C. N. Rensen: Endocrinology, LUMC, Leiden, Netherlands;Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, Netherlands - Abstract:
Backgrounds
South Asians have a higher risk to develop obesity and related disorders compared to white Caucasians. This may in part be due to their lower resting energy expenditure (REE) which coincides with less energy-combusting brown adipose tissue (BAT). Since blockade of endocannabinoid signaling increases BAT activity and over-activation of
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