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Cleaning tumor margins via abrogation of heat shock protein 90 with protein engineered tri-block biopolymer-geldanamycin conjugates

  • In: SUBMITTED ORALS on Tuesday, 15 April 2014, 13:00-14:30
  • At: PSWC, Melbourne (Australia) (2014)
  • Type: Presentation
  • By: CHEN, Yizhe (University of Utah, Pharmaceutics and Pharmaceutical Chemistry, Salt lake city, United States of America)
  • Co-author(s): Youn, Pilju (University of Utah, Salt lake city, United States of America)
    Furgeson, Darin (University of Utah, Salt lake city, United States of America)
  • Abstract:

    I. Hepatocellular carcinoma (HCC) remains a lethal cancer with extremely low survival rates. First line clinical therapies, such as thermal ablation, suffer tumor recurrence rates near 40%. Incomplete ablation at tumor margins, poor drug formulation, and lack of drug targeting are suggested as major causes of poor clinical outcomes. Heat shock


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Last update 28 September 2023

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