Solid dispersions tadalafil-Soluplus® formed by high-energy ball milling.
Impact of process parameters.
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-C-043-Monday
- By: KRUPA, Anna (Jagiellonian University, Medical College, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Krakow, Poland)
- Co-author(s): Anna Krupa: Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College Faculty of Pharmacy, Krakow, Poland
Dorota Majda: Faculty of Chemistry, Jagiellonian University, Krakow, Poland
Katarzyna Dziewic: Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College Faculty of Pharmacy, Krakow, Poland
Renata Jachowicz: Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College Faculty of Pharmacy, Krakow, Poland - Abstract:
Backgrounds
Tadalafil is a high melting point poorly soluble drug. Thus, the amorphisation methods, which can be carried out at room temperature, and are organic solvents-free need to be optimized with the aim to improve its solubility.
Aims
The aim of this study was to investigate the impact of high-energy ball milling process parameters: (i)
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Last update 28 September 2023