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Tackling anti-microbial resistance, development of novel metallo-ß-lactamase inhibitors

  • In: Symposium A3: Systems approaches in drug discovery & Design on Tuesday, 23 May 2017, 17:15-17:50
  • At: Stockholm (Sweden) (2017)
  • Type: Presentation
  • By: BREM, Jurgen (Oxford University, Chemistry, Oxford, United Kingdom)
  • Co-author(s): Jurgen Brem: Chemistry, Oxford University, Oxford, United Kingdom
  • Abstract:

    The β-lactams remain the most important antibiotics in clinical use. The most important type of resistance to them is mediated via β-lactamases. The recent clinical introduction of avibactam as a serine-β-lactamase inhibitor is a major advance. However, the metallo-β-lactamases are of particular concern because they catalyse the hydrolysis of


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Last update 28 September 2023

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