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Application of derivative ratio spectrophotometry and partial least squares pls to the determination of dissociation constants.

  • In: SIG Quality of Pharmaceuticals - Poster Session
  • At: Cairo (Egypt) (2005)
  • Type: Poster
  • Poster code: QP-P-007
  • By: WAHBI, Abdelaziz (University of Alexandria, Pharm. Analytical Chemistry, Alexandria, Egypt)
  • Co-author(s): Fahmy (University of Alexandria, ALEXANDRIA, Egypt)
    Moneeb (University of Alexandria, ALEXANDRIA, Egypt)
  • Abstract:

    Dissociation constants of some compounds have been determined using (i) derivative ratio spectrophotometry, (ii) multivariate methods using absorbances and absorbance ratio data. For the PLS method, the training set was constructed by computation using a general formula UAa + DAb where U+D= 1 and Aa and Ab are the absorbances of the completely..

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Last update 28 September 2023

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