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Pharmacokinetic study of enclosed adenosine diphosphate and outer lipid component after the administration of h12-(adp)-liposome as a synthetic platelet substitute

  • In: Posters G - Pharmacokinetics (PK), Pharmacodynamics (PD) and Systems Pharmacology
  • At: PSWC, Melbourne (Australia) (2014)
  • Type: Poster
  • Poster code: PG-001
  • By: TAGUCHI, Kazuaki (Sojo University, Faculty of Pharmaceutical Sciences, Kumamoto, Japan)
  • Co-author(s): Ujihira, Hayato (Kumamoto university, Kumamoto, Japan)
    Ogaki, Sigeru (Kumamoto university, Kumamoto, Japan)
    Watanabe, Hiroshi (Kumamoto university, Kumamoto, Japan)
    Takeoka, Shinji (Waseda university, Tokyo, Japan)
    Ikeda, Yasuo (Waseda university, Tokyo, Japan)
    Handa, Makoto (Keio University, Tokyo, Japan)
    Otagiri, Masaki (Sojo University, Kumamoto, Japan)
    Maruyama, Toru (Kumamoto university, Kumamoto, Japan)
  • Abstract:

    [Background]Adenosine diphosphate (ADP)-encapsulated liposomesmodified with a fibrinogen g-chain dodecapeptide (HHLGGAKQAGDV, H12) [H12-(ADP)-liposome]was developed as a new type of synthetic platelet alternative. [Aims] The aim of thisstudy is to characterize the pharmacokinetic properties of theH12-(ADP)-liposomes and components from the..

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Last update 28 September 2023

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