Export this Abstract | Print this Abstract | Add to my preferred Abstracts list | My preferred Abstracts list (3) | Back to Search
A quality-by-design approach for highly systematic optimization of lipid-polymer hybrid nanoparticles toward efficient and safe intracellular delivery of siRNA cargo
- In: Short Communications C2 on Tuesday, 23 May 2017, 11:15-12:30
- At: Stockholm (Sweden) (2017)
- Type: Presentation
- By: THANKI, Kaushik (University of Copenhagen, Department of Pharmacy, Copenhagen, Denmark)
- Co-author(s): Kaushik Thanki: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
Xianghui Zeng: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
Sarah Justesen: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark;Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
Sarah Tejlmann: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
Emily Falkenberg: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
Hanne Mørck Nielsen: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
Henrik Franzyk: Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
Camilla Foged: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark - Abstract:
Backgrounds
RNA interference therapy is highly target-specific and is mediated by small interfering RNA (siRNA).Aims
The aim of the study was to apply a quality-by-design approach for the systematic optimization of siRNA-loaded lipid-polymer hybrid nanoparticles (LPNs) composed of lipid-like materials (lipidoids) and poly(DL-lactide-co-glycolide.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
Please login
Last update 28 September 2023