A comparison of two different self immolative linker strategies in the design of lymph directing, triglyceride mimetic prodrugs of buprenorphine
- In: Short Communications A2 on Monday, 22 May 2017, 13:30-15:00
- At: Stockholm (Sweden) (2017)
- Type: Presentation
- By: HAN, Sifei (Monash University, Drug Delivery, Disposition and Dynamics, Parkville, Australia)
- Co-author(s): Sifei Han: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
Luojuan Hu: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
Tim Quach: Medicinal Chemistry, Monash University, Parkville, Australia
Shea Lim: Medicinal Chemistry, Monash University, Parkville, Australia
Natalie Trevaskis: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
Jamie Simpson: Medicinal Chemistry, Monash University, Parkville, Australia
Christopher Porter: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia - Abstract:
Backgrounds
The oral bioavailability of buprenorphine (BUP) is limited by hepatic first-pass metabolism. Exploiting drug transport through the lymphatic system provides a means to circumvent first pass metabolism, since the intestinal lymph drains into the systemic circulation via the thoracic duct, bypassing the liver. Previous studies have
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Last update 28 September 2023