PEGylation relieves lipid nanoparticle-induced neuroinflammatory response in mouse brain and enhanced brain delivery for targeting ischemia
- In: Short Communications B3 on Tuesday, 23 May 2017, 11:15-12:30
- At: Stockholm (Sweden) (2017)
- Type: Presentation
- By: LU, Yingmei (Zhejiang University City College, Hangzhou, China)
- Co-author(s): Yingmei Lu: School of Medicine, Zhejiang University City College, HangZhou, China
Nannan Lu: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
Dongmei Gong: School of Medicine, Zhejiang University City College, HangZhou, China
Yixuan Yin: School of Medicine, Zhejiang University City College, HangZhou, China
Tiantian Cui: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
Xing Lv: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
Yue Pan: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
Yijie Liu: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
Fangying Yu: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
Feng Han: College of pharmaceutical sciences, Zhejiang university, HangZhou, China - Abstract:
Backgrounds
The host immune response as well as neurotoxicity of nanoparticle is an impediment to clinical translation. The evidences regarding stability and safety of nanoparticles is still lacking.
Aims
Reduce the nanoparticle-induced neuroinflammatory response and create a novel nanoparticle, which have a great promise for use in therapies
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