Design, Synthesis and Testing of novel small molecule inhibitors of S-phase Kinase-Associated Protein 2
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-022-Monday
- By: LIU, Ran (Belrose, Australia)
- Co-author(s): Ran Liu: Faculty of Pharmacy, University of Sydney, Sydney, Australia
Paul Groundwater: Faculty of Pharmacy, University of Sydney, Sydney, Australia
David Hibbs: Faculty of Pharmacy, University of Sydney, Sydney, Australia
Thomas Grewal: Faculty of Pharmacy, Universit - Abstract:
Backgrounds
S-Phase Kinase-associated Protein 2 (Skp2), an oncoprotein, is overexpressed in numerous human cancers and plays a critical role in cell cycle progression, senescence, cancer progression and metastasis, through promoting th
Aims
Our project aims to develop small molecules which inhibit the interaction of Skp2 and p27, a process which is
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Last update 28 September 2023