Influence of lipophilicity and hydrogen bond formation on passive diffusion of small-molecule drugs across hexadecane-based artificial cell membranes
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-043-Monday
- By: THORMANN, Ursula (Uppsala University, Pharmacy, Uppsala, Sweden)
- Co-author(s): Ursula Thormann: Department of Pharmacy, Uppsala University, Uppsala, Sweden
Bradley Doak: Department of Chemistry, Uppsala University, Uppsala, Sweden;Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia
Per Larsson: Department of Pharmacy, Uppsala University, Uppsala, Sweden
Matteo Rossi Sebastiano: Department of Chemistry, Uppsala University, Uppsala, Sweden
Maria Backlund: Department of Pharmacy, Uppsala University, Uppsala, Sweden;Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Science for Life Laboratory, Uppsala, Sweden
Georgios Imanidis: Institute of Pharma Technology, University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland;Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
Jan Kihlberg: Department of Chemistry, Uppsala University, Uppsala, Sweden
Pär Matsson: Department of Pharmacy, Uppsala University, Uppsala, Sweden - Abstract:
Backgrounds
Intramolecular hydrogen bond (IMHB) formation has been suggested as a valuable tool to increase drug permeability.Aims
The aim was to assess the impact of IMHB and other molecular properties on small-molecule diffusion across hexadecane membranes.Methods
A hexadecane-based artificial membrane assay (HDM-PAMPA) was developed to mimic the.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023