The Effect of Protein Binding on the Interaction Between Transporters and Highly Protein Bound Drugs
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-066-Monday
- By: BOWMAN, Christine (San Francisco, United States)
- Co-author(s): Christine Bowman: Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, United States
Hideaki Okochi: Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, United States
Leslie Benet: Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, United States - Abstract:
Backgrounds
Accurately predicting hepatic clearance from in vitro results is crucial in the selection process of new molecular entities for clinical development. However, current in vitro-in vivo extrapolation methods often lead to underprediction, particularly for compounds that are highly protein bound and substrates for uptake transporters.Aims
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Last update 28 September 2023