Evaluation of transport of tyrosine kinase inhibitors across the blood-brain barrier in the pericyte-deficient state
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-087-Monday
- By: MIHAJLICA, Nebojsa (Uppsala University, Pharmaceutical Biosciences, Uppsala, Sweden)
- Co-author(s): Nebojsa Mihajlica: Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
Christer Betsholtz: Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Margareta Hammarlund-Udenaes: Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden - Abstract:
Backgrounds
Pericytes play an important role in the maintenance of blood-brain barrier (BBB) transport properties. Tyrosine kinase inhibitors (TKIs) are drugs which have limited transport across the functional BBB, mainly due to active efflux processes.
Aims
To evaluate the role of pericytes in BBB transport, by assessing several TKIs in a
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Last update 28 September 2023