Lipid mimetic, lymph-directing prodrugs of testosterone facilitate oral bioavailability via avoidance of first-pass metabolism
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-B-083-Tuesday
- By: HU, Luojuan (Monash University, Faculty of Pharmacy and Pharmaceutical Sciences, Melbourne, Australia)
- Co-author(s): Luojuan Hu: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
Sifei Han: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
Tim Quach: Medicinal Chemistry, Monash University, Melbourne, Australia
Shea Lim: Medicinal Chemistry, Monash University, Melbourne, Australia
Natalie Trevaskis: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
Jamie Simpson: Medicinal Chemistry, Monash University, Melbourne, Australia
Christopher Porter: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia - Abstract:
Backgrounds
Hepatic first-pass metabolism limits the oral bioavailability of drugs such as testosterone (TST). Drug transport through the lymphatic system avoids first pass metabolism since intestinal lymph drains into the systemic circulation via the thoracic duct, bypassing the liver. Dietary triglyceride (TG) is transported via the lymphatics
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Last update 28 September 2023