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3D QSAR-guided identification of oxazole and triazole derivatives as novel, potent and selective S1P1 agonists
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-049-Monday
- By: WANG, Xiaojian (Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Medicinal Chemistry, Beijing, China)
- Co-author(s): Xiaojian Wang: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Dali Yin: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Qiong Xiao: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Meiyang Xi: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Hui Wen: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Xiang Zhang: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Huaqing Cui: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China - Abstract:
Backgrounds
Recently, the Sphingosine 1-phosphate receptor (S1P-R) signaling system has proven to be of biological and medical importance in immune regulation, including blood vessel constriction, heart rate modulation, angiogenesis, etc.Aims
To design novel, potent and selective S1P1 agonists with improved pharmacokinetic profiles based on the.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023