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Effect of Drug Uptake Transporters on Fluvastatin Pharmacokinetics in Rats
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-067-Tuesday
- By: OKOCHI, Hideaki (UCSF, BTS, SAN FRANCISCO, United States)
- Co-author(s): Hideaki Okochi: Department of Bioengineering & Therapeutic Sciences, University of California San Francisco, San Francisco, United States
Leslie Benet: Department of Bioengineering & Therapeutic Sciences, University of California San Francisco, San Francisco, United States - Abstract:
Backgrounds
Fluvastatin (FLST), a highly hydrophilic and extensively metabolized HMG-CoA reductase inhibitor, is categorized as Biopharmaceutical Drug Disposition Classification class 1 and suggested not to be affected by drug transporters in in vivo pharmacokinetics (PK). However, the Extended Clearance Classification System suggests that FLST, an
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Last update 28 September 2023