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Physiologically-based approach to predict dopamine D2 receptor occupancy of antipsychotics in brain: translation from rat to human
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-092-Tuesday
- By: WONG, Yin Cheong (Leiden University, Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands)
- Co-author(s): Yin Cheong Wong: Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden Univeristy, Leiden, Netherlands
Maddalena Centanni: Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden Univeristy, Leiden, Netherlands
Elizabeth de Lange: Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands - Abstract:
Backgrounds
Receptor occupancy (RO) is a translational biomarker for assessing drug efficacy, which could facilitate both dose optimization of existing drugs and evaluation of drug candidates.
Aims
We aimed to apply a physiologically-based pharmacokinetic (PBPK) modeling approach to predict the dopamine D2 RO of antipsychotics.
Methods
Risperidone
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Last update 28 September 2023