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Introduction of a new in vitro approach for prediction of drug-drug interactions based on measurement of intracellular unbound concentrations of time-dependent inhibitors of CYP3A4
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-B-041-Tuesday
- By: FILPPULA, Anne (Uppsala, Sweden)
- Co-author(s): Rezvan Parvizi: Department of Pharmacy, Uppsala University, Uppsala, Sweden
Anne M Filppula: Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Uppsala, Sweden
André Mateus: Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Uppsala, Sweden
Pawel Baranczewski: Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Uppsala, Sweden
Per Artursson: Department of Pharmacy, Uppsala University, Uppsala, Sweden;Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Uppsala, Sweden;SciLifeLab Drug Discovery and Development Platform, ADME of Therapeutics facility, Department of Pharmacy, Uppsala University, Uppsala, - Abstract:
Backgrounds
Time-dependent inhibition (TDI) of cytochrome P450 (CYP) 3A4 may result in severe and long-lasting clinical drug-drug interactions (DDIs). However, predictions based on in vitro TDI data tend to over-estimate the risk of DDIs, likely due to conservative inhibitor concentration estimates (Vieira et al, 2014).Aims
The aim of this study was .. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023