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Approaches to up-regulate P-glycoprotein for the treatment of Alzheimer's disease
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-016-Tuesday
- By: NEWMAN, Stephanie (Melbourne, Australia)
- Co-author(s): Stephanie Newman: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
Yijun Pan: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
Jennifer Short: Drug Discovery Biology, Monash University, Melbourne, Australia
Joseph Nicolazzo: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia - Abstract:
Backgrounds
P-glycoprotein (P-gp) at the blood-brain barrier (BBB) mediates the brain-to-blood clearance of β-amyloid (Aβ) and is down-regulated in Alzheimer's disease (AD). Interestingly, the mood-stabilising drug lithium, has been associated with a reduced incidence of AD in humans. In vitro studies indicate that lithium chloride (LiCl) can.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023