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The β-lactam Clavulanic Acid without Antibacterial Activity mediates Glutamate Transport-sensitive Pain-relief in the Chronic Constriction Injury Rat Model of Neuropathic Pain
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-029-Tuesday
- By: BJERRUM, Ole Jannik (University of Copenhagen, Drug design and pharmacology, Copenhagen, Denmark)
- Co-author(s): Pernille Kristensen: Drug design and pharmacology, University of Copenhagen, Copenhagen, Denmark
Georgi Gegelashvili: Instittute of Chemical Biology, Ilia State University, Tbilisi, Georgia
Gordon Munro: Dept. Neurology, Glostrup Hospital, Glostrup, Denmark
Anne-Marie Heegaard: Drug design and pharmacology, University of Copenhagen, Copenhagen, Denmark
Ole Jannik Bjerrum: Drug design and pharmacology, University of Copenhagen, Copenhagen, Denmark - Abstract:
Backgrounds
Following nerve injury, down-regulation of astroglial glutamate transporters (GluTs) and subsequently extracellular glutamate accumulation is one of the factors contributing to nociceptive signaling. Some β-lactam antibiotics e.g. ceftriaxone can upregulate GluTs and display analgesic effect in chronic pain models. Following nerve.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023