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Drug-target binding influences target- and tissue selectivity.
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-066-Tuesday
- By: DE WITTE, Wilbert (Leiden Academic Centre for Drug Research, Pharmacology, Leiden, Netherlands)
- Co-author(s): Wilhelmus E. A. de Witte: Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands
Hendrika C. Vlot: Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands
Piet H. van der Graaf: Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands;Quantitative Systems Pharmacology, Certara, Canterbury, United Kingdom
Meindert Danhof: Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands
Gerard J. P. van Westen: Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden, Netherlands
Elizabeth C. M. de Lange: Pharmacology, Leiden Academic Centre for Drug Research, Leiden, Netherlands - Abstract:
Backgrounds
Drug-target binding kinetics has received increasing interest in drug discovery, due to its influence on the time course of the drug effect.Aims
In this study, we aim to determine how drug-target binding kinetics, target concentrations and tissue characteristics can be used to predict selectivity over time.
Methods
We investigated the
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Last update 28 September 2023